mecA is not involved in the sigmaB-dependent switch of the expression phenotype of methicillin resistance in Staphylococcus epidermidis.

نویسندگان

  • Johannes K-M Knobloch
  • Sebastian Jäger
  • Jörn Huck
  • Matthias A Horstkotte
  • Dietrich Mack
چکیده

A lack of sigma(B) activity reduces methicillin resistance in heterogeneous Staphylococcus epidermidis 1057, whereas inactivation of the anti-sigma factor RsbW switched the phenotype to homogeneous expression of resistance. Oxacillin induction of mecA transcription is reduced in a sigma(B)-negative strain. However, mecA is not involved in the switch of expression phenotype.

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Correlation of Minimum Inhibitory Concentration Breakpoints and Methicillin Resistance Gene Carriage in Clinical Isolates of Staphylococcus epidermidis

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 49 3  شماره 

صفحات  -

تاریخ انتشار 2005